Impaired Working Memory in Patients with Mild Disabled Relapsing-Remitting Multiple Sclerosis and it’s Relation with Depression and Fatigue

Document Type : Research Paper

10.22059/japr.2014.52547

Abstract

The multiple sclerosis (MS) is a chronic disease of CNS leads to some dysfunctions including cognitive (working memory), mood (depression) and fatigue. In spite of previous investigations about working memory impairment in patients with MS, there are scare evidences for working memory dysfunction in mild disabled MS patients (EDSS<3.5). Moreover the correlation between working memory and depression and fatigue was the other aim of the present study. 25 patients with RR-MS (with EDSS<3.5) were recruited by a neurologist according to the Mc Donald criteria and then 27 age-, gender-, and education-matched healthy controls participants were selected. After completing Beck depression Inventory and fatigue severity scale, PASAT was performed by both groups. The patients with MS had significantly higher level of depression symptoms and fatigue and lower scores of PASAT than healthy controls. The PASAT performance in patients with MS was no significant correlation with their depression and fatigue. In addition to more depressive symptoms and fatigue, impairment of working memory was seen in patients with MS. But their dysfunction of working memory was not related to their depression or fatigue.

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History

  • Receive Date: 23 June 2013
  • Revise Date: 22 January 2012
  • Accept Date: 06 March 2014
  • First Publish Date: 21 March 2014
  • Publish Date: 21 March 2014

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