The present study was conducted to investigate the effectiveness of object relations-based analytic couple therapy on distress tolerance and marital burnout of women affected by marital infidelity. The present research method was semi-experimental with a pre-test-post-test design with a control group and a two-month follow-up period. The statistical population of the present study was women affected by infidelity who referred to counseling and family psychotherapy services centers in the north of Tehran in the summer of 2024. 35 women were selected through purposive sampling method and randomly accommodated into experimental and control groups (18 women in the experimental group and 17 women in the control group). The experimental group received relations-based analytic couple therapy (8 sessions) during eight weeks. The applied questionnaires in this study included Distress Tolerance Questionnaire (DTQ) and Marital Burnout Questionnaire (MBQ). The data taken from the study were analyzed through mixed ANOVA and Bonferroni follow-up test via SPSS23 software. The results showed that relations-based analytic couple therapy is effective on the distress tolerance (F=46.35; Eta=0.58; P<0.001) and marital burnout (F=35.40; Eta=0.51; p<0.001) of the women affected by marital infidelity. As a result, object-relations-based analytic couple therapy, by familiarizing women with information related to their own