مقایسه طیف توان الکتروانسفالوگرافی بین بیماران مبتلا به‌ سندرم روده تحریک‌پذیر و افراد سالم

نوع مقاله: مقاله پژوهشی

نویسندگان

1 دانشجوی دکتری روان‌شناسی سلامت، دانشکده روان‌شناسی و علوم تربیتی دانشگاه تهران، تهران، ایران

2 استاد گروه روانشناسی ،دانشکده روانشناسی و علوم تربیتی دانشگاه تهران، تهران، ایران

3 استاد گروه روانشناسی ، دانشکده روانشناسی و علوم تربیتی، دانشگاه تهران،تهران، ایران

4 محقق گروه روان‌پزشکی دانشگاه تورنتو، تورنتو، کانادا

5 دانشیارگروه گوارش، دانشکده پزشکی، دانشگاه علوم پزشکی تهران، تهران، ایران

چکیده

هدف از پژوهش حاضر، مقایسه توان نوسانات جاری مغزی با استفاده از الکتروانسفالوگرافی در حالت استراحت بین افراد مبتلا به ‌IBS و گروه سالم بود. مطالعه حاضر، از نوع بنیادی- کاربردی بود و با توجه به‌ مقایسه متغیرهای پژوهش در دو نمونه از افراد مبتلا به ‌IBS و افراد سالم، طرح پژوهش از نوع علّی- مقایسه‌ای به‌شمار می‌رود. جامعه آماری شامل تمامی بیماران مبتلا به ‌IBS مراجعه‌کننده به‌ کلینیک گوارش بیمارستان شریعتی و کلینیک گوارش مسعود در شهر تهران از سال 97-1394 بود. بدین‌ منظور 11 نفر (7 زن و 4 مرد) بیمار مبتلا به ‌IBS و 11 نفر (7 زن و 4 مرد) سالم که از نظر سن و جنسیت با گروه بیمار همتاسازی شده بودند، انتخاب شدند و نوسانات مغزی آن‌ها با استفاده از 64EEG   کاناله در حالت استراحت و با چشمان بسته ثبت شد. نوسانات مغزی با روش تبدیل فوریه سریع و آزمون t مستقل مورد تجزیه‌و‌تحلیل قرار گرفت. نتایج به‌دست آمده از تحلیل طیف توان نشان داد که گروه بیمار نسبت به‌گروه کنترل، توان بالاتری را در باند فرکانسی تتا (8-4 هرتز) در همه کانال‌ها نشان می‌دهد (0/05>p). افزیش توان تتا در بیماران مبتلا به ‌IBS، ممکن است در درد مزمن این بیماران نقش داشته باشد و یا پیامد نشانه‌های تجربه‌شده توسط بیماران باشد.

کلیدواژه‌ها


عنوان مقاله [English]

The Comparison of Electroencephalography Power Spectrum Between Patients with Irritable Bowel Syndrome and Healthy People

نویسندگان [English]

  • Sepideh Dehghani 1
  • Mohammad Ali Besharat 2
  • Reza Rostami 3
  • Reza Zomorrodi 4
  • Homayoun Vahedi 5
1 department of psychology, university of Tehran, Tehran, Iran
2 Department of Psychology, University of Tehran, Tehran, Iran
3 Department of Psychology, Faculty of psychology and Educational Science, University of Tehran, Tehran, Iran
4 Project Scientist, Department of Psychiatry, University of Toronto, Toranto, Canada
5 Tehran University of medical sciences, Tehran, Iran
چکیده [English]

The aim of this study was to compare the power of ongoing oscillatory activity by using electroencephalography (EEG) between patients with IBS and healthy individuals. The present study was a basic-applied research and regarding the comparison of variables between IBS and healthy group, the study was designed as casual-comparative. The statistical population included patients with IBS who were referred to digestive clinic of Shariati hospital and Masoud digestive clinic in Tehran from 2015-2019. 11 IBS patients (7 female and 4 male) and 11 healthy (7 female and 4 male), gender and age-matched, were selected and brain oscillations were recorded by a 64-channel EEG at rest in eye-closed condition. Oscillations were analyzed by fast Fourier transform and independent t test. The results of power spectrum analysis showed that the IBS patients had augmented theta (4-8 Hz) power in all channels (p<0/05). Increased theta power in IBS patients may contribute to chronic pain or represent the outcome of symptoms.

کلیدواژه‌ها [English]

  • irritable bowel syndrome
  • frequency band
  • power spectrum
Aizawa, E., Sato, Y., Kochiyama, T., Saito, N., Izumiyama, M., Morishita, J., ... & Fukudo, S. (2012). Altered cognitive function of prefrontal cortex during error feedback in patients with irritable bowel syndrome, based on FMRI and dynamic causal modeling. Gastroenterology. 143(5), 1188-1198.

Bjørk, M. H., Stovner, L. J., Engstrøm, M., Stjern, M., Hagen, K., & Sand, T. (2009). Interictal quantitative EEG in migraine: a blinded controlled study. The Journal of Headache and Pain. 10(5), 331-339.

Cavanagh, J. F., & Frank, M. J. (2014). Frontal theta as a mechanism for cognitive control. Trends in Cognitive Sciences. 18(8), 414-421.

Chang, J. Y., Locke III, G. R., McNally, M. A., Halder, S. L., Schleck, C. D., Zinsmeister, A. R., & Talley, N. J. (2010). Impact of functional gastrointestinal disorders on survival in the community. The American Journal of Gastroenterology. 105(4), 822-832.

Cohen, M. X. (2014). Analyzing Neural Time Series Data: Theory and Practice.
Cambridge, MA: The MIT Press.

Defrees, D. N., & Bailey, J. (2017). Irritable Bowel Syndrome: Epidemiology, Pathophysiology, Diagnosis, and Treatment. Primary Care. 44(4), 655-671.

Delorme, A., & Makeig, S. (2004). EEGLAB: an open source toolbox for analysis of single-trial EEG dynamics including independent component analysis. Journal of Neuroscience Methods. 134(1), 9-21.

dos Santos Pinheiro, E. S., de Queiros, F. C., Montoya, P., Santos, C. L., do Nascimento, M. A., Ito, C. H., ... & Sá, K. N. (2016). Electroencephalographic patterns in chronic pain: a systematic review of the literature. PLoS One. 11(2), e0149085.

Dos Santos Pinheiro, E. S., de Queiros, F. C., Montoya, P., Santos, C. L., do Nascimento, M. A., Ito, C. H., ... & Sá, K. N. (2016). Electroencephalographic patterns in chronic pain: a systematic review of the literature. PloS one. 11(2), 773-782.

Dressler, O., Schneider, G., Stockmanns, G., & Kochs, E. F. (2004). Awareness and the EEG power spectrum: analysis of frequencies. British Journal of Anesthesia. 93(6), 806-809.

Drossman, D. A. (2016). Functional gastrointestinal disorders: history, pathophysiology, clinical features, and Rome IV. Gastroenterology. 150(6), 1262-1279.

Fallon, N., Chiu, Y., Nurmikko, T., & Stancak, A. (2018). Altered theta oscillations in resting EEG of fibromyalgia syndrome patients. European Journal of Pain. 22(1), 49-57.

Gaman, A., & Kuo, B. (2008). Neuromodulatory processes of the brain–gut axis. Neuromodulation: Technology at the Neural Interface. 11(4), 249-259.

Glover, G. H. (2011). Overview of functional magnetic resonance imaging. Neurosurgery Clinics. 22(2), 133-139.

González-Roldán, A. M., Cifre, I., Sitges, C., & Montoya, P. (2016). Altered dynamic of EEG oscillations in fibromyalgia patients at rest. Pain Medicine. 17(6), 1058-1068.

Gunnarsson, J., & Simrén, M. (2009). Peripheral factors in the pathophysiology of irritable bowel syndrome. Journal of Digestive and Liver Disease. 41(11), 788-793.

Icenhour, A., Witt, S. T., Elsenbruch, S., Lowén, M., Engström, M., Tillisch, K., ... & Walter, S. (2017). Brain functional connectivity is associated with visceral sensitivity in women with Irritable Bowel Syndrome. NeuroImage: Clinical. 15(4), 449-457.

Jensen, M. P., Sherlin, L. H., Gertz, K. J., Braden, A. L., Kupper, A. E., Gianas, A., ... & Hakimian, S. (2013). Brain EEG activity correlates of chronic pain in persons with spinal cord injury: clinical implications. Spinal Cord. 51(1), 55-58.

Kennedy, P. J., Clarke, G., O‘Neill, A., Groeger, J. A., Quigley, E. M. M., Shanahan, F., ... & Dinan, T. G. (2014). Cognitive performance in irritable bowel syndrome: evidence of a stress-related impairment in visuospatial memory. Psychological Medicine. 44(7), 1553-1566.

Khan, S., & Chang, L. (2010). Diagnosis and management of IBS. Nature Reviews Gastroenterology & Hepatology. 7(10), 565-581.

Kumar, D., Thompson, P. D., Wingate, D. L., Vesselinova-Jenkins, C. K., & Libby, G. (1992). Abnormal REM sleep in the irritable bowel syndrome. Gastroenterology. 103(1), 12-17.

Kwan, C. L., Diamant, N. E., Pope, G., Mikula, K., Mikulis, D. J., & Davis, K. D. (2005). Abnormal forebrain activity in functional bowel disorder patients with chronic pain. Neurology. 65(8), 1268-1277.

LeBlanc, B. W., Lii, T. R., Silverman, A. E., Alleyne, R. T., & Saab, C. Y. (2014). Cortical theta is increased while thalamocortical coherence is decreased in rat models of acute and chronic pain. PAIN®. 155(4), 773-782.

Linedale, E. C., & Andrews, J. M. (2017). Diagnosis and management of irritable bowel syndrome: A guide for the generalist. Medical Journal of Australia. 207(7), 309-315.

Liu, X., Li, S. J., Shaker, R., Silverman, A., Kern, M., Ward, D. B., ... & Sood, M. R. (2017). Reduced Functional Connectivity between the Hypothalamus and High-order Cortical Regions in Adolescent Patients with Irritable Bowel Syndrome. Journal of Pediatric Gastroenterology and Nutrition. 65(5), 516-519.

Llinás, R., Urbano, F. J., Leznik, E., Ramírez, R. R., & Van Marle, H. J. (2005). Rhythmic and dysrhythmic thalamocortical dynamics: GABA systems and the edge effect. Trends in Neurosciences. 28(6), 325-333.

Lovibond, P. F., & Lovibond, S. H. (1995). The structure of negative emotional states: Comparison of the Depressions Anxiety Stress Scales (DASS) with the Beck Depression and Anxiety Inventories. Journal of Behavior Research and Therapy. 33(3), 335-343.

Mayer, E. A. (2011). Gut feelings: the emerging biology of gut–brain communication. Nature Reviews Neuroscience. 12(8), 453-466.

Mayer, E. A., Labus, J. S., Tillisch, K., Cole, S. W., & Baldi, P. (2015). Towards a system view of IBS. Nature Reviews Gastroenterology & Hepatology. 12(10), 592-605.

Mayer, E. A., Naliboff, B. D., & Chang, L. (2002). Evolving pathophysiological model of functional gastrointestinal disorders: implications for treatment. The European Journal of Surgery. Supplement.=Acta chirurgica. Supplement. (587), 3-9.

Mayer, E. A., Naliboff, B. D., & Craig, A. B. (2006). Neuroimaging of the brain-gut axis: from basic understanding to treatment of functional GI disorders. Gastroenterology. 131(6), 1925-1942.

Ngernyam, N., Jensen, M. P., Arayawichanon, P., Auvichayapat, N., Tiamkao, S., Janjarasjitt, S., ... & Auvichayapat, P. (2015). The effects of transcranial direct current stimulation in patients with neuropathic pain from spinal cord injury. Clinical Neurophysiology. 126(2), 382-390.

Niddam, D. M., Tsai, S. Y., Lu, C. L., Ko, C. W., & Hsieh, J. C. (2011). Reduced hippocampal glutamate–glutamine levels in irritable bowel syndrome: preliminary findings using magnetic resonance spectroscopy. The American Journal of Gastroenterology. 106(8), 1503-1511.

Noda, Y., Zomorrodi, R., Saeki, T., Rajji, T. K., Blumberger, D. M., Daskalakis, Z. J., & Nakamura, M. (2017). Resting-state EEG gamma power and theta–gamma coupling enhancement following high-frequency left dorsolateral prefrontal rTMS in patients with depression. Clinical Neurophysiology. 128(3), 424-432.

Nomura, T., Fukudo, S., Matsuoka, H., & Hongo, M. (1999). Abnormal electroencephalogram in irritable bowel syndrome. Scandinavian journal of Gastroenterology. 34(5), 478-484.

Phillips, K., Wright, B. J., & Kent, S. (2014). Irritable bowel syndrome and symptom severity: Evidence of negative attention bias, diminished vigour, and autonomic dysregulation. Journal of Psychosomatic Research. 77(1), 13-19.

Raghavachari, S., Lisman, J. E., Tully, M., Madsen, J. R., Bromfield, E. B., & Kahana, M. J. (2006). Theta oscillations in human cortex during a working-memory task: evidence for local generators. Journal of Neurophysiology. 95(3), 1630-1638.

Saha, L. (2014). Irritable bowel syndrome: pathogenesis, diagnosis, treatment, and evidence-based medicine. World Journal of Gastroenterology. 20(22), 6759-6773.

Sarnthein, J., Stern, J., Aufenberg, C., Rousson, V., & Jeanmonod, D. (2006). Increased EEG power and slowed dominant frequency in patients with neurogenic pain. Brain. 129(1), 55-64.

Sayuk, G. S., & Gyawali, C. P. (2015). Irritable bowel syndrome: modern concepts and management options. The American Journal of Medicine. 128(8), 817-827.

Shuster, J., & Toplak, M. E. (2009). Executive and motivational inhibition: Associations with self-report measures related to inhibition. Consciousness and Cognition. 18(2), 471-480.

Silverman, D. H., Munakata, J. A., Ennes, H. E. L. E. N. A., Mandelkern, M. A., Hoh, C. K., & Mayer, E. A. (1997). Regional cerebral activity in normal and pathological perception of visceral pain. Gastroenterology. 112(1), 64-72.

Stern, J., Jeanmonod, D., & Sarnthein, J. (2006). Persistent EEG over activation in the cortical pain matrix of neurogenic pain patients. Neuroimage. 31(2), 721-731.

Taber, K. H., Wen, C., Khan, A., & Hurley, R. A. (2004). The limbic thalamus. The Journal of Neuropsychiatry and Clinical Neurosciences. 16(2), 127-132.

Tayama, J., Sagami, Y., Shimada, Y., Hongo, M., & Fukudo, S. (2007). Effect of alpha‐helical CRH on quantitative electroencephalogram in patients with irritable bowel syndrome. Neurogastroenterology & Motility. 19(6), 471-483.

Urigüen, J. A., & Garcia-Zapirain, B. (2015). EEG artifact removal—state-of-the-art and guidelines. Journal of Neural Engineering. 12(3), 031001.

Vuckovic, A., Hasan, M. A., Fraser, M., Conway, B. A., Nasseroleslami, B., & Allan, D. B. (2014). Dynamic oscillatory signatures of central neuropathic pain in spinal cord injury. The Journal of Pain. 15(6), 645-655.

Walton, K. D., Dubois, M., & Llinas, R. R. (2010). Abnormal thalamocortical activity in patients with Complex Regional Pain Syndrome (CRPS) type I. Pain. 150(1), 41-51.

Wensaas, K. A., Langeland, N., Hanevik, K., Mørch, K., Eide, G. E., & Rortveit, G. (2012). Irritable bowel syndrome and chronic fatigue 3 years after acute giardiasis: historic cohort study. Gut. 61(2), 214-219.

Zielińska, A., Sałaga, M., Włodarczyk, M., & Fichna, J. (2018). Chronic abdominal pain in irritable bowel syndrome–current and future therapies. Expert Review of Clinical Pharmacology. 11(7), 729-739.